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UNILAG SICKLE CELL RESEARCH GROUP

College of Medicine, University of Lagos, idi-Araba Campus, Lagos

Following the directive of the Vice Chancellor of the University of Lagos on the formation of research groups and after consultations between Prof M.O. Kehinde, (Dept. of Medicine) and Prof S. I. Jaja (Dept. of Physiology) a meeting of researchers in sickle cell was convened for the 18th January 2017. The meeting was held at the Departmental Library, Dept. of Physiology, College of Medicine of the University of Lagos at 2pm.

Present at that inaugural meeting were: Prof MO Kehinde (Medicine), Prof SI Jaja, (Physiology), Dr KO Soyebi (Radiation Biology, Radiotherapy and Radiodiagnosis), Dr OK Ale (Medicine), Dr RW Braimoh (Medicine), Dr VO Osunkalu (Haematology and Blood Transfusion), Dr RW Kalejaiye (Medicine) and Dr SI Ogungbemi (Physiology). Since then, Dr NO Imaga (Biochemistry), Dr OA Olowoyeye (Radiation Biology, Radiotherapy and Radiodiagnosis), Dr TA Adeyemo (Haematology and Blood Transfusion) and Dr OM Babalola (Biochemistry) have joined the group.

It was noted that the sickle cell disease is essentially an African burden. The incidence of sickle cell disease (SCD) in Africa is between 5% and 40% with 120,000 to 200,000 babies born each year. It is also estimated that in Nigeria about 85,000 neonates with the sickle cell gene are born each year.

NAME, MOTTO AND LOGO

After extensive discussion members agreed and adopted the name UNILAG SICKLE CELL RESEARCH GROUP. The group also approved its motto: SUCCOUR THROUGH RESEARCH. A logo as shown (above) has also been approved.

OBJECTIVES

The objectives of the sickle Cell Research Group are to:

  • Conduct collaborative research in sickle cell disease
  • Organize seminars and conferences on sickle cell disease
  • Create awareness on sickle cell disease and its current management.

MEMBERSHIP

This includes all interested academic staff (irrespective of discipline or faculty) of the University of Lagos, Lagos, Nigeria and external researchers and concerned organizations globally.

AFFILIATIONS AND LINKAGES

These include Lagos University Teaching Hospital (LUTH), National Sickle Cell Foundation, Lagos and other yet to be identified local and foreign research groups or bodies.

FINANCIAL SUPPORT

The research group will receive financial support from any willing and approved local or foreign grantor/donor.

RESEARCH GRANTS PREVIOUSLY OBTAINED BY MEMBERS

  1. University of Lagos Research Grant: CRC No. 2008/05. Research Grant to the tune of  three million,  two hundred and twelve thousand naira plus two hundred and fifty dollars  (N 3,212,000. oo + $250.0) awarded by the Central Research Committee of University of Lagos. (Grant awarded to Jaja S.I., Kehinde M.O., Temiye E.O. and Ogungbemi S.O. in April 2010). Title of Project: Effect of L-Arginine Supplementation on Nitric Oxide level, Osmotic fragility and Free Radical Status in Sickle Cell Anemia.

 

SOME PUBLICATIONS OF MEMBERS

  •            Jaja S.I., Opesanwo O., Mojiminiyi F.B.O. and Kehinde M. O. (2000). Lung function, hemoglobin and irreversibly sickled cells in sickle cell patients. West Afr. J. Med. 19(3), 225 – 229.

 

  • Jaja S. I., Kehinde M.O., Gbenebitse S., Mojiminiyi F.B.O. and Ogungbemi A.I. (2000). Effect of Vitamin C on arterial blood pressure, irreversibly sickled cells and osmotic fragility in sickle cell anemia subjects.  J. Physiol. Sci. 16(1&2), 14 - 18.

 

  • Jaja S.I. Gbenebitse S., Aworinde O., Mojiminiyi F.B.O. and Kehinde M.O. (2001). Effect of vitamin E on arterial blood pressure, osmotic fragility and irreversibly sickled cells in sickle cell patients. Med. J. 40(3), 63 - 66.

 

  • Jaja S.I., Aisuodionwe S.I., Kehinde M.O. and Gbenebitse S. (2002). The effect of vitamin C and/or warmth on forearm blood flow and vascular resistance in sickle cell anemia subjects. Postgraduate Med. J. 9(2); 92 – 94.

 

  • Jaja S.I., Ikotun A.R., Gbenebitse S. and Temiye E.O. (2002). Blood pressure, hematologic and erythrocyte fragility changes in children suffering from sickle cell anemia following ascorbic acid supplementation. Trop. Pead. 48 (6); 366 – 370.

 

  • Jaja S.I., Gbadamosi A.I., Kehinde M.O. and Gbenebitse S. (2003). The effect of warmth or/and vitamin E supplementation on forearm blood flow and forearm vascular resistance in sickle cell and non sickle cell anemia subjects. Postgraduate Med J. 10(1); 6 - 12.

 

  • Jaja S.I., Aisuodionwe S., Gbenebitse S. and Kehinde M.O. (2003). Effect of vitamin C supplementation on vascular responses induced by warmth or cold stimulation in normal Nigerians. Qt. J. Hosp. Med. 13(1-2); 61 – 64.

 

  • Gbenebitse S., Jaja S.I. and Kehinde M.O. (2005). Effect of changes in plasma vitamin E levels on vascular responses and lipid peroxidation in sickle cell anemia subjects. Postgraduate Med. J. 12(2); 81 – 84.

 

  • Jaja S. I., Aigbe P.E., Gbenebitse S. and Temiye E.O. (2005). Changes in erythrocytes following supplementation with alpha-tocopherol in children suffering from sickle cell anemia. Postgraduate Med. J. 12(2); 110 – 114.

 

  • Jaja S.I., Kehinde M.O. and Ogungbemi S.I. (2008) Cardiac and autonomic responses to change in posture or vitamin C supplementation in sickle cell anemia subjects. Pathophysiol 15, 25 – 30

 

  • Ogungbemi S.I., Jaja S.I. and Kehinde M.O. (2008). Baro-reflex sensitivity is augmented more in athletes than in sickle cell anemia subjects following vitamin C supplementation. Nigerian Journal of Health and Biomedical Sciences 7(2): 1 – 8.

 

  • Kehinde, O.,  Jaja S.I., Adewumi O.M., Adeniyi A.I., Nezianya M.O., and Ayinla E.O. (2010). Liver enzymes and trace elements in the acute phase of sickle cell anaemia. West Afr J Med. 29(4): 244-248.

 

  • Olowoyeye , Jaja S. I., Kehinde M.O., Awosanya G.O., Irurhe N.K., Adeyomoye A.A., Soyebi K.O., Arogundade R.A., Adekunle O.M., Soneye B.K. and Tubi O.O. (Sept/Oct 2011). Effects of Ascorbic acid intake on the intima media thickness and blood flow velocities of the carotid artery in sickle cell anemic subjects. J. Diagnostic Medical Sonography. 27 (5): 214-219.

 

  • Jaja S.I., Kehinde M.O., Olowoyeye O.A., Shoneye K.O., Tubi O.O. and Adekunle O.O (2013). Vitamin C increases catalase but decreases liver enzymes and lipid peroxidation in sickle cell anemia subjects in the steady state. Nig. J. Hosp. Med. 23(3): 232-236.

 

  • Ogungbemi S.I., Anigbogu C.N., Kehinde M.O. and Jaja S.I. (2013). L-Arginine increases nitric oxide and attenuates pressor and heart rate responses to change in posture in sickle cell anemia subjects. Niger J Physiol Sci. 28: 45-50.

 

  • Kehinde M.O., Ogungbemi S.I.,Anigbogu C.N.,and Jaja S.I. (2015). L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects. 22(3): 137 – 142.

 

  • Jaja S.I., Ogungbemi S.O., Kehinde M.O., and Anigbogu C.N. (2016). Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia. 23(2): 81 – 85.
  • Ngozi Awa Imaga (2015). Nutraceuticals in the Management of Sickle Cell Anemia, In: Nutraceuticals and Functional Foods in Human Health and Disease Prevention. Edited by Debasis Bagchi, Harry G. Preuss, Anand Swaroop. CRC Press, Taylor & Francis, USA. ISBN 9781482237214.https://www.crcpress.com/Nutraceuticals-and-Functional-Foods-in-Human-Health-and-Disease-Prevention/Bagchi-Preuss-Swaroop/p/book/9781482237214

 

  • Imaga NOA, Chukwu C.E, Blankson A., Gbenle G. O. (2013). Biochemical Assessment of Ciklavite used as a Nutraceutical in Sickle Cell Anemia Management Journal of Herbal Medicine 3(4): 137-148. DOI: 10.1016/j.hermed.2013.05.003
  • M. Fatai, N. O. A. Imaga and G. O. Gbenle (2013). Biochemical Investigations into the Effects of Co-administration of Ciprofloxacin and Nicosan. African Journal of Pharmacy and Pharmacology vol. 7(39):2674-2679. DOI: 0.5897/AJPP2013.3516

 

  • Ngozi Awa Imaga (2013). Phytomedicines and Nutraceuticals: Alternative therapeutics for Sickle Cell Anemia. The Scientific World Journal, 2013, Article ID 269659, 12 pages. DOI: 10.1155/2013/269659 PubMed PMID 23476125
  • Imaga NOA, Ukpo, G.E., Owolabi, M.A, Shekoni AI., Gbenle G. O. (2012). In vivo analyses of the effects of co-administration of Carica papaya leaf extract with ciprofloxacin. African Journal of Pharmacy and Pharmacology 6(48): 3268-3273.  DOI: 10.5897/AJPP12.528
  • Imaga Ngozi O. A., Shaire Esther A., Ogbeide Samson and Samuel K. Akindele (2011). In vitro Biochemical Investigations of the effects of Carica papaya and Fagara Zanthoxyloides on Antioxidant Status and Sickle Erythrocytes. African Journal of Biochemistry Research. 5(8), pp. 226-236
  • O. A. Imaga, G. O. Gbenle, V. I. Okochi, S.O. Adenekan, S. O. Edeoghon, M. O. Kehinde, S. B. Bamiro., A. Ajiboye and A. Obinna (2010). Antisickling and Toxicological Profile of Parquetina nigrescens. Journal of Medicinal Plants Research vol. 4 (8) 639-643
  • Ngozi Awa Imaga, George O. Gbenle,    Veronica I. Okochi,   Sunday Adenekan, Tomi Duro-Emmanuel, Bola Oyeniyi, Patience N. Dokai, Mojisola Oyenuga, Alero Otumara  and  Felix C. Ekeh (2010). Phytochemical and Antioxidant Nutrient Constituents of Carica papaya and Parquetina nigrescens Scientific Research & Essays vol. 5 (16) 2201-2205
  • Ngozi Awa Imaga and Olusegun A. Adepoju (2010). Analyses of Antisickling Potency of Carica papaya dried leaf extract and fractions Journal of Pharmacognosy and Phytotherapy vol. 2(7) 97-102
  • Imaga, Ngozi O.A., Adenekan S. O., Yussuph G.A, Nwoyimi T.I., Balogun O.O. and Eguntola T.A. (2010). Assessment of Antioxidation Potential of Selected Plants with Antisickling Property. Journal of Medicinal Plants Research vol. 4(21) 2217-2221
  • O. A. Imaga (2010). The Use of Phytomedicines as Effective Therapeutic agents in Sickle Cell Anemia. Scientific Research & Essays vol. 5 (24) 3803-3807
  • Imaga, N. O. A, Gbenle, G. O., Okochi, V. I., Akanbi S. O., Edeoghon, S.O., Oigbochie, V, Kehinde, M. O. and Bamiro, S.B. (2009). Antisickling Property of Carica papaya leaf extract. African Journal of Biochemistry Research vol. 3 (4) 102-106

 

OFFICERS

There are no elected officers of the group yet. However, Prof SI Jaja is acting as Convener while Dr SI Ogungbemi is the Ag. Secretary.

MEETINGS

Currently meetings are held every 2 weeks at the Departmental Library, Department of Physiology, College of Medicine of the University of Lagos at Idi Araba. Meetings start at 2pm.

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